Postdoctoral Scientist – Antibody-RNA Conjugation, Genetic Medicine, Lilly

Job Description

We are seeking a highly motivated postdoctoral fellow to join our Genetic Medicine team at Eli Lilly in Boston MA.  The successful candidate will possess a strong background in synthetic organic chemistry and experience in molecular design. They will be responsible for designing, synthesizing, and characterizing novel linkers for drug conjugates, with a focus on effective extrahepatic delivery. As part of a platform team, this individual will formulate linker chemistry strategies and investigate kinetics of payload-linker release to advance the RNA modality. Success in this role requires ability to solve complex problems, challenge the status-quo, and excel in communication and collaboration within a multidisciplinary team-oriented environment.

Job Responsibilities:

• Develop novel linker strategies for antibody-RNA conjugates and bioconjugation methodologies. Design and synthesize novel linkers for controlled drug release.
• Collaborate closely with ADME teams to develop robust bioanalytical methods and to investigate PK/PD relationships for antibody-RNA conjugates.
• Contribute to optimization of internal antibody-RNA conjugate workflow.
• Work productively and safely in the laboratory; and maintain good practice in writing experimental reports in an electronic lab notebook.
• Communicate experimental results and project progress with supervisor and at team/department meetings.
• Publish/share original research externally (presentations, peer-reviewed articles, and conferences).

Basic Qualifications:

• Ph.D. in synthetic chemistry, chemical biology, or related scientific field with all completed requirements by September 2025.

Additional Skills/Preferences:

• Extensive knowledge of cutting-edge modern organic chemistry, linker design and complex molecule synthesis.
•  Understanding advanced analytical and purification techniques.
• Experience in antibody-drug conjugates and/or oligonucleotide chemistry will be preferred.
• Proficiency in independently executing research tasks.
• High learning agility in the field of new scientific concepts and drug modalities.
• Strong problem-solving skills with creative solutions in constructing complex molecular systems.
• A proven track record of significant contributions to research projects, substantiated by first or co-authorship on peer-reviewed scientific publications.
• A track record of productive collaborations in interdisciplinary team environment.
• Excellent communication and organizational skills

Additional Information:

• This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete

Link: https://careers.lilly.com/us/en/job/LILLUSR87220EXTERNALENUS/Postdoctoral-Scientist-Antibody-RNA-Conjugation-Genetic-Medicine?

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