Scientist, CAMRIS, USA

Job Description

We are seeking a Scientist to support the National Institutes of Health’s (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference.

CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today’s most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs.

Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.

Responsibilities

• Support the Downstream Process Development (purification) group of the Vaccine Production Program (VPP) at the Vaccine Research Center.
• Develop downstream processes for recombinant proteins such as monoclonal antibodies, subunit or nanoparticle vaccines, and virus-like particles (VLPs) that may be used as clinical therapeutic or vaccine candidates.
• Work independently and collaboratively within the purification group to design, develop and optimize chromatography, Tangential Flow Filtration (TFF), and Normal Flow Filtration (NFF) processes for all clinical trial vaccine candidates.
• Apply process optimization techniques, such as Design of Experiments (DoE) or other statistical design approaches.
• Support Viral Clearance Validation studies by traveling to CMO/CRO sites to perform and oversee viral clearance chromatography and filtrations processes.
• Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups at the VRC.
• Analyze and compile data, present at various group/department meetings.
• Pursue novel technologies to advance the capabilities of the VPP.
• Write and review technical reports and method protocols.
• Write and review process batch records for toxicology batch productions.
• Write and review technology transfer documents in support of GMP manufacturing.

Qualifications

• Ph.D. in Biochemistry, Chemical Engineering, or other life sciences is required.
• Minimum of eight or more (8+) years of experience is required.
• Demonstrated knowledge of maintaining accurate and detailed records.
• Demonstrated proficiency in the following techniques or tools for protein purification and characterization:
• Column chromatography for protein purification by means of AEX, CEX, affinity, SEC, HIC.
• AKTA chromatography system.
• Qualitative assays including SDS-PAGE and Western Blot.
• UV/vis spectrophotometer.
• Proficiency in the following is highly-desirable, but not required:
• Column packing and testing.
• Lab scale TFF systems.
• Lab scale nano-filtration systems.
• Qualitative assays including SDS-PAGE and Western Blot.
• UV/vis spectrophotometer.
• Strong oral and written communication skills.
• Familiarity with computer software including word processing and data evaluation.

Physical Requirements:

The physical requirements described here are representative of those that must be met by a candidate to perform the essential functions of this job. Reasonable accommodations may be provided to enable individuals with disabilities to perform essential job functions.

Must be able to wear personal protective equipment (PPE), including gloves, face shields/goggles, safety glasses, safety shoes, lab coat and disposable dust/surgical mask.

Ability to lift or carry less than 25 pounds, push or pull less than 25 pounds, reach above shoulder level and use both hands.

Required to stand or walk more than 25 of 30 min., bend repeatedly and climb.

Must have depth perception, correctable near vision, and distinguish basic colors.

Will perform repetitive activities.

Ability to work alone, closely with others, on ladders or scaffolding and work with hands in water.

Will be required to be in contact with lasers (open or closed) in instrument.

Will work with corrosive substances, inorganic dust and powders, heavy metals, plastics, solvents and sensitizing agents.

Link: https://careers-camris.icims.com/jobs/6648/scientist/job

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