Senior Scientist I/II, Peptide Formulations and Drug Delivery

Job Description

AbbVie is seeking a highly motivated, talented and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Senior Scientist I/II position in Lake County, IL. The primary role of this position is to serve as an MPDD project leader on discovery programs, providing preclinical formulation support for initial safety and efficacy assessments. The candidate will work collaboratively with discovery and development partners across disciplines to improve delivery of drug candidates and advance formulations to clinical development with improved developability profiles. The desired candidate will have a strong background in drug delivery and hands-on experience in physicochemical characterization for the preclinical development of peptides, small molecules, and biologics candidates. The ideal candidate will have experience with a range of formulation techniques for various modalities. Familiarity with identifying strategies to overcome in vivo drug delivery barriers, and proficiency with dosage forms including nanoparticles, amorphous systems and lipids is expected. Experience with lipid nanoparticles (LNPs) and siRNA conjugates is a plus.

Key responsibilities include:

• Design and develop innovative formulation and delivery strategies for peptide drugs to overcome in vivo tissue barriers and enhance therapeutic efficacy.
• Develop and optimize scalable processes for robust manufacturing of peptide drug formulations.
• Conduct physicochemical characterization of peptide drug formulations using advanced techniques to assess stability, solubility, and other critical properties.
• Interpret and communicate results from characterization and formulation studies to advise the selection of peptide drug candidates with properties suitable for development.
• Stay abreast of emerging technologies and scientific advancements in peptide drug delivery.
• Author publications and present at scientific conferences.
  

Qualifications

Basic:

• BS (12+ yrs. experience), MS (10+ yrs. experience) or PhD (4+ yrs experience) in Pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/Biomedical Engineering, and Materials Science.
• Ph.D. candidates with pertinent research exposure are also encouraged to apply.
• Job level will be commensurate with academic and/or industrial work experience.
  

Preferred:

• Fundamental knowledge of the physiological barriers to drug delivery and absorption, including various transport mechanisms.
• Working knowledge of drug formulation approaches and routes of administration (i.e. IV, SC, IP, PO).
• Familiarity with the role of physicochemical properties in drug delivery and formulation design.
• Experience with analytical and physicochemical characterization of pharmaceutical dosage forms. Techniques of interest include, but are not limited to: HPLC, UPLC, MS, DLS, DSC, FTIR, TGA, DVS, PXRD, dissolution, and microscopy, etc.
• Knowledge of preclinical and clinical formulation development principles relevant to peptide drugs.
• Excellent self-management and organizational skills.
• Demonstrated ability to work collaboratively in a cross functional team setting.
  

Link: https://careers.abbvie.com/en/job/senior-scientist-i-ii-peptide-formulations-and-drug-delivery-in-north-chicago-il-jid-16870?

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