Job Description

The successful candidate will help to establish pre-clinical capabilities within GSK’s new oligo synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what’s possible in oligonucleotide therapeutics.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:

• Establish pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries.
• Develop and maintain high-throughput automation workflows.
• Perform hands-on work, establish oligo synthesis workflows and draft SOPs in support of next generation chemistry and method development.
• Serve as the oligo synthesis SME for the team, representing oligo synthesis in various cross matrix meetings.
• Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results.
• Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Train and/or build a small team to support synthesis capabilities.
• Collaborate and communicate across various teams to build robust workflows, or leverage internal resources to deliver on portfolio endpoints.

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Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD with 2+ years, or MS with 4+ or BS with 8+ years’ experience in chemistry or chemical biology or related field.
• 2+ years of industry experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis.
• Familiarity with Mermade 192X with Poseidon software and ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics.
• Expertise in oligonucleotide synthesis (SPOS), and biological familiarity of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors).

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Minimum MS with 4+ years or above (or PhD +2) in Oligonucleotide synthesis and/or oligo chemistry
• Prior experience with team leadership, scientific and professional mentorship, and project management.
• Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions.
• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.
• Experience with oligonucleotide conjugation chemistries is desirable but not required.
• Sense of urgency, flexibility, independence and accountability.
• Ability to communicate both verbally and in writing with all levels both inside and outside of the organization.
• Maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Must be a committed team player prepared to work in and embrace a team-based culture.

#Li-GSK

Link: https://gsk.wd5.myworkdayjobs.com/GSKCareers/job/USA—Massachusetts—Cambridge/Sr-Principal-Scientist-Principal-Scientist_421943